Eye-Risk

Exploring the combined role of genetic and non-genetic factors that lead to AMD: a system-level analysis of disease subgroups, risk factors and pathways

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This proposal will exploit existing longitudinal cohort studies from the European Eye Epidemiology Consortium (E3) and from clinic-based bio-banks, to validate currently known genetic and non-genetic risk factors for age-related macular degeneration (AMD). It will also investigate their interaction, test and interpret their pathophysiological consequences at the molecular level, and establish individualized risk profiles according to the different subgroups of AMD patients.

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