Exploring the combined role of genetic and non-genetic factors that lead to AMD: a system-level analysis of disease subgroups, risk factors and pathways
This proposal will exploit existing longitudinal cohort studies from the European Eye Epidemiology Consortium (E3) and from clinic-based bio-banks, to validate currently known genetic and non-genetic risk factors for age-related macular degeneration (AMD). It will also investigate their interaction, test and interpret their pathophysiological consequences at the molecular level, and establish individualized risk profiles according to the different subgroups of AMD patients.
BMF publications in the EYE.RISK project:
- Monés, J., Garcia, M., Biarnés, M., Lakkaraju, A., & Ferraro, L. (2017). Drusen Ooze: A Novel Hypothesis in Geographic Atrophy. Ophthalmology Retina.
- Monés, J., & Biarnés, M. (2017). Geographic atrophy phenotype identification by cluster analysis. British Journal of Ophthalmology, bjophthalmol-2017.
- Colijn JM, Buitendijk GHS, Prokofyeva E, Alves D, Cachulo ML, Khawaja AP, et al. Prevalence of Age-Related Macular Degeneration in Europe: The Past and the Future. Ophthalmology. (2017), vol. 124, no 12, p. 1753-1763
- van Leeuwen E, Emri E, Merle B, Colijn JM, Kersten E, Cougnard-Gregoire A, Dammeier S, Meester-Smoor M, Pool FM , de Jong E, Delcourt C, Rodrigez-Bocanegra E, Biarnés M, Luthert P, Ueffing M, Klaver C, Nogoceke E, den Hollander A, Lengyel I. (2018). A new perspective on lipid research in age-related macular degeneration. Progress in Retinal and Eye Research.
- Biarnés M, Vassiliev V, Nogoceke E, Emri E, Rodríguez-Bocanegra E, Ferraro L, García M, Fauser S, Monés J, Lengyel I, Peto T. Precision medicine for age-related macular degeneration: current developments and prospects. Expert Review of Precision Medicine and Drug Development, (2018)
For more information you can access to the project in ResearchGate.