Integrated Use of Second Harmonic Generation (SHG) Microscopy to Image Corneal Collagen Fibrils and Adaptive Optics Scanning Laser Ophthalmoscopy (AOSLO) to Image the Photoreceptors.

The development of Advanced Laser Imaging Techniques for the Anterior and Posterior Eye (LITE) is a project that involves the creation of a hybrid system that will allow for new eye imaging techniques for the treatment of retinal and corneal pathologies. These new techniques will provide access to high-resolution images of both the retina’s photoreceptors and the collagen fibres of the cornea, through the latest adaptive optical methods.

The new system will provide a higher-accuracy diagnosis at the cellular level, affording better knowledge of retinal diseases and offering new, more precise effectiveness assessment parameters. This forms part of new up-and-coming experimental therapies, such as regenerative medicine treatments with stem cell implantation, for degenerative retinal diseases that are currently at a want for effective treatment and which are associated with severe vision loss.