GA Characterization of geographic atrophy progression in patients with age-related macular degeneration: evolution and risk factors associated with geographic atrophy progression (GAIN)
This study aims to describe the natural history of geographic atrophy and identify the potential risk factors associated with the faster spread of atrophy, as well as to better characterise autofluorescence and to explore the use of high-resolution optical coherence tomography of progressive changes for the development of rational therapies.
This study is providing new insights into the characterization of the progression of geographic atrophy, the different speed rates of progression and the types of patients at higher risk of visual loss. New tomographic findings of the microscopic features of the outer retinal layers have been described and reported recently. These new findings and data may be crucial to better assess the impact and follow-up of new up-and-coming therapies.